Listar por autor "Fernández-Moreno, Mercedes"

Mostrando ítems 1-20 de 20

    • A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis 

      Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)
      [Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ...

    • Anti-inflammatory activity of APPA (Apocynin and Paeonol) in human articular chondrocytes 

      Fernández-Moreno, Mercedes; Hermida-Gómez, Tamara; Larkins, Nicholas; Reynolds, Alan; Blanco García, Francico J (MDPI, 2024-01-16)
      [Abstract] Osteoarthritis (OA) is a chronic joint disease leading to cartilage loss and reduction in the joint space which results in pain. The current pharmacological treatment of OA is inadequate and pharmacological ...

    • Generating Rho-0 cells using mesenchymal stem cell lines 

      Fernández-Moreno, Mercedes; Hermida Gómez, Tamara; Gallardo, M. Esther; Dalmao-Fernández, Andrea; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J (PLoS, 2016-10-20)
      [Abstract] Introduction, The generation of Rho-0 cells requires the use of an immortalization process, or tumor cell selection, followed by culture in the presence of ethidium bromide (EtBr), incurring the drawbacks its ...

    • Genetic diversity in fishery-exploited populations of the banded murex ("Hexaplex trunculus") from the southern Iberian Peninsula 

      González-Tizón, Ana M.; Fernández-Moreno, Mercedes; Vasconcelos, Paulo; Gaspar, Miguel; Martínez-Lage, Andrés (Elsevier, 2008-08)
      [Abstract] This study presents an analysis of the genetic diversity in Hexaplex trunculus from three localities of the southern Iberian Peninsula (Ria Formosa and Ria de Alvor in Portugal, and Río Piedras in Spain) using ...

    • Impaired metabolic flexibility in the osteoarthritis process: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Lund, Jenny; Hermida Gómez, Tamara; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Blanco García, Francisco J; Fernández-Moreno, Mercedes (MDPI, 2020-03-27)
      [Abstract] Osteoarthritis (OA) is the most frequent joint disease; however, the etiopathogenesis is still unclear. Chondrocytes rely primarily on glycolysis to meet cellular energy demand, but studies implicate impaired ...

    • In vitro comprehensive analysis of VA692 a new chemical entity for the treatment of osteoarthritis 

      Cheleschi, Sara; Calamia, Valentina; Fernández-Moreno, Mercedes; Biava, Mariangela; Giordani, Antonio; Fioravanti, Antonella; Anzini, Maurizio; Blanco García, Francisco J (Elsevier, 2018-08-25)
      [Abstract] Selective cyclooxigenase (COX)-2 inhibitors were developed to prevent traditional non-steroidal anti-inflammatory drugs (tNSAIDs) gastro-intestinal adverse effects. VA692, a recently disclosed selective COX-2 ...

    • Increased synovial immunohistochemistry reactivity of TGF-β1 in erosive peripheral psoriatic arthritis 

      Pinto-Tasende, José A.; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Fernández-López, Carlos; Oreiro, Natividad; de-Toro, Javier; Blanco García, Francico J (BioMed Central, 2023-03-30)
      [Abstract] Background: Immune and non-immune cells contribute to the pathology of chronic arthritis, and they can contribute to tissue remodeling and repair as well as disease pathogenesis. The present research aimed to ...

    • Is osteoarthritis a mitochondrial disease?: what is the evidence 

      Fernández-Moreno, Mercedes; Rego-Pérez, Ignacio; Blanco García, Francico J (Wolters Kluwer, 2022-01)
      [Abstract] Propose of review: To summarize the evidence that suggests that osteoarthritis (OA) is a mitochondrial disease. Recent findings: Mitochondrial dysfunction together with mtDNA damage could contribute to cartilage ...

    • iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis 

      Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)
      [Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ...

    • Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis 

      Blanco García, Francisco J; Fernández-Moreno, Mercedes (Elsevier, 2020-05-14)
      [Abstract] Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, ...

    • Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (BioMed Central, 2011-11-22)
      [Abstract] Background: Oxidative stress play a main role in the initiation and progression of the OA disease and leads to the degeneration of mitochondria. To prevent this, the chondrocytes possess a well-coordinated ...

    • Mitochondrial DNA (mtDNA) haplogroups influence the progression of knee osteoarthritis: data from the Osteoarthritis Initiative (OAI) 

      Soto-Hermida, Ángel; Fernández-Moreno, Mercedes; Oreiro, Natividad; Fernández-López, Carlos; Pértega-Díaz, Sonia; Cortés-Pereira, Estefanía; Rego-Pérez, Ignacio; Blanco García, Francisco J (PLoS, 2014-11-12)
      [Abstract] OBJECTIVE: To evaluate the influence of the mtDNA haplogroups on knee osteoarthritis progression in Osteoarthritis Initiative (OAI) participants through longitudinal data from radiographs and magnetic resonance ...

    • Mitochondrial DNA (mtDNA) haplogroups J and H are differentially associated with the methylation status of articular cartilage: potential role in apoptosis and metabolic and developmental processes 

      Cortés-Pereira, Estefanía; Fernández-Tajes, Juan; Fernández-Moreno, Mercedes; Vázquez-Mosquera, María E.; Relaño, Sara; Ramos-Louro, Paula; Durán-Sotuela, Alejandro; Dalmao-Fernández, Andrea; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (Wiley, 2019-02-12)
      [Abstract] Objective. To analyze the influence of mitochondrial genome variation on the DNA methylome of articular cartilage. Methods. DNA methylation profiling was performed using data deposited in the NCBI Gene ...

    • Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids 

      Dalmao-Fernández, Andrea; Hermida Gómez, Tamara; Lund, Jenny; Vázquez-Mosquera, María E.; Rego-Pérez, Ignacio; Garesse, Rafael; Blanco García, Francisco J; Fernández-Moreno, Mercedes (Elsevier, 2022-05)
      [Abstract] With the redefinition of osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness with a low grade of chronic inflammation. Mitochondrial dysfunction ...

    • Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts: a meta-analysis and functional study 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Vázquez-Mosquera, María E.; Cortés-Pereira, Estefanía; Relaño, Sara; Hermida Gómez, Tamara; Pértega-Díaz, Sonia; Oreiro, Natividad; Fernández-López, Carlos; Garesse, Rafael; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2016-12-05)
      [Abstract] Objective To evaluate the influence of the mitochondrial DNA (mtDNA) haplogroups in the risk of incident knee osteoarthritis (OA) and to explain the functional consequences of this association to identify potential ...

    • Mitochondrial haplogroups define two phenotypes of osteoarthritis 

      Fernández-Moreno, Mercedes; Soto-Hermida, Ángel; Oreiro, Natividad; Pértega-Díaz, Sonia; Fernández-López, Carlos; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2012-05-11)
      [Abstract] Objective: To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). Methods: Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; ...

    • mtDNA Haplogroup A Enhances the Effect of Obesity on the Risk of Knee OA in a Mexican Population 

      Ramos-Louro, Paula; Arellano Pérez Vertti, Rubén Daniel; López Reyes, Alberto; Martínez-Nava, Gabriela Angélica; Espinosa, Rolando; Pineda, Carlos; González-Galarza, Faviel Francisco; Argüello Astorga, Rafael; Aguilar Muñiz, Lizette Sarai; Hernández Terán, Fernando; Parra Torres, Nancy Marbella; Durán Sotuela, Alejandro; Fernández-Moreno, Mercedes; Balboa-Barreiro, Vanesa; Blanco García, Francisco J; Rego-Pérez, Ignacio (Nature, 2022-03-25)
      [Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ...

    • Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes 

      Vázquez-Mosquera, María E.; Fernández-Moreno, Mercedes; Cortés-Pereira, Estefanía; Relaño, Sara; Dalmao-Fernández, Andrea; Ramos-Louro, Paula; Durán Sotuela, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2021-06-15)
      [Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...

    • Soluble inflammatory mediators of synoviocytes stimulated by monosodium urate crystals induce the production of oxidative stress, pain, and inflammation mediators in chondrocytes 

      López-Reyes, Alberto; Medina-Luna, Daniel; Santamaría-Olmedo, Mónica; Martínez-Flores, Karina; Zamudio-Cuevas, Yessica; Fernández-Torres, Javier; Martínez-Nava, Gabriela Angélica; Olivos-Meza, Anell; Camacho-Rea, Carmen; Fernández-Moreno, Mercedes; Blanco García, Francisco J; Pineda, Carlos (Springer, 2021-03-16)
      [Abstract] We hypothesized that the secretion of inflammatory mediators from synoviocytes affects the chondrocyte homeostasis of articular cartilage. This study was a preliminary attempt to elucidate the molecular mechanisms ...

    • Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12 

      Pérez-García, Selene; Carrión, Mar; Villanueva-Romero, Raúl; Hermida Gómez, Tamara; Fernández-Moreno, Mercedes; Mellado, Mario; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (Wiley, 2019-03-22)
      [Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...